Sentence examples for the brain burden from inspiring English sources

Studies have shown that proton pump inhibitors (PPIs) increase the brain burden of amyloid-beta (Aβ) and also create vitamin B12 deficiency.

If the seat of memory is located in the brain, the burden of proof remains with the empirical sciences to account for the metaphysical status of memory and mental content.

The worldwide incidence of Alzheimer's disease (AD) is increasing with estimates that 115 million individuals will have AD by 2050, creating an unsustainable healthcare challenge due to a lack of effective treatment options highlighted by multiple clinical failures of agents designed to reduce the brain amyloid burden considered synonymous with the disease.

We define the brain Aβ burden of an AD mouse as 100%% and the reduction of brain Aβ by adding an additional peripheral system as 68%% of the brain Aβ burden of the AD mice as indicated in our study.

This protocol resulted in a significant reduction of 46% in the brain cyst burden compared to the Control+boost group and of 54% compared to naïve mice.

The SAG1 group showed a significant reduction in the brain cyst burden (30%) compared to control and naïve groups while these two last groups presented a similar brain parasite load.

To analyze the immunoprotective value, two weeks after the last immunization, mice were orally challenged with a non-lethal dose of ME49 cysts and one month later the brain parasite burden was measured.

Reasonable and statistically significant correlation was found between fly and mice data for day 7 p.i. in the target organs liver (r=0.47, P<0.001) and kidney (r=0.37, P<0.001) (Fig. 4A,B), whereas in general the brain organ burden showed poorer correlation with the fly survival rate.

Significant features of hα-syn spreading in rats include (i) the targeting of preferred anatomical sites, (ii) a consistent sequence of histological progression, and (iii) bilateral but asymmetric brain burden.

Studies of the temporal evolution of AD's biomarkers have shown that, in AD, the brain's amyloid burden correlates poorly with cognitive decline.

The best storytellers carry their ideas in the brain like a burden.