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Patients and surgeons who favor strongly a particular treatment approach are usually reluctant to participate in trials where operative intervention is determined on the basis of randomization.
Allocation was preassigned on the basis of randomization numbers and was concealed from the subjects, the investigators, and the researchers who recruited and assessed participating subjects.
The trials were assessed on the basis of randomization, concealment of treatment allocation, blinding, completeness of follow-up, and the use of intention-to-treat analysis.
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Included patients were divided randomly into either the LRA or RRA group on the basis of the randomization list.
Patients were allocated on the basis of unstratified block randomization (block size: 4) to the intervention group (aVQ) or no additional therapy (control group) according to a randomization list.
This tool assesses quality of randomized controlled trials on the basis of the reported quality of randomization, blinding, and adequate descriptions of subject withdrawals and dropouts.
In most of the studies included in our meta-analysis, it appears that patients were not selected on the basis of variability in SBP before randomization, as is usually done when antihypertensive compounds are developed.
The availability of individual patient data will allow exploration of whether the benefits or hazards of treatment with ARBs or β-blockers are particularly great in certain types of patient, defined on the basis of characteristics present at the time of randomization.
The extent of randomization and coverage of variant sequences flanking the motif are the basis of designing and synthesis of the partial randomized pool.
Randomization was stratified on the basis of concomitant mood stabilizers being taken (lithium, anticonvulsants, and antipsychotics).
Patients were submitted to block randomization and stratified on the basis of their initial SAPS II exp score.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com