They worked on the basis of experience, blind hope and an informed guess where the best point of survival might be for the trapped men.
Study design: We studied 15 children with a definite diagnosis of CMSE on the basis of a blind challenge, 12 children with suspected cases of CMSE, 11 children with celiac disease, and 12 control children.
Abatacept is FDA approved for the treatment of JIA alone and in combination with methotrexate on the basis of a double-blind withdrawal study [ 99].
In 2009, the FDA approved abobotulinumtoxinA to temporarily improve the appearance of moderate to severe glabellar lines (also based on the 4-point wrinkle severity scale) in adult patients younger than 65 years of age on the basis of 3 double-blind randomized studies, with a total of 600 subjects.
Pulmonary function tests (PFT) were ordered by physicians caring for these patients on the basis of clinical indications, while blinded to the experimental immunologic assays.
We did not exclude studies on the basis of allocation concealment or blinding.
These data formed the basis of the ongoing double-blind, placebo-controlled, randomized phase III international trial in 660 previously treated patients.
A meta-analysis including 1,896 patients was performed on the basis of six controlled, double-blind, multiple-dose studies, regardless of sample size or duration of follow-up.
Consenting comparison offspring were recruited from families in which neither parent met DSM-IV criteria for a lifetime major psychiatric disorder (psychotic, mood, substance use disorders) on the basis of SADS-L interviews and blind consensus diagnostic review.
While it would be inappropriate to assume inadequate blinding merely on the basis of inadequate reporting, equally, the assumption of adequate blinding when reporting is absent or inadequate cannot be justified.
