Sentence examples for the basic defect from inspiring English sources

The specific effects on the proteome observed here can be attributed to the basic defect in NBS, defective DNA repair [14].

However, new therapies modulating defective CFTR, the basic defect underlying CF, have started to hit the clinic and several others are in trial or in development.

For Plato, democracy suffered from the basic defect of putting decision-making in the hands of people who were not competent to decide.

And, while this drug targets a very specific form of cystic fibrosis that occurs in only four per cent of patients, the fact that similar drugs — which are also intended to address the basic defect in the faulty CFTR protein and which have shown promising results in initial laboratory trials — are being developed by Vertex and other companies seems to signal a new treatment paradigm.

The basic defect of CF is associated with a failure to conduct chloride through CFTR.

"Starting in children may prevent the disease process developing if we correct the basic defect early in life.

A clinical method for detecting changes in airway liquid absorption could provide a means of screening medications designed to correct the basic defects of CF lung disease.

Prof Stuart Elborn, who led the European part of the trial from Queen's University Belfast, told the BBC News website: "This is very exciting and it really demonstrates that we can correct the basic defects in cystic fibrosis.

The basic defects of representative primary and secondary immunodeficiencies are discussed in relation to observed immunologic consequences.

One of the basic defects observed in Cep126-depleted cells is the lack of a centrosome-focused MT array.

Further, they have provided the paediatrician with a better understanding of the deficiencies in current treatment options, as, in the majority of conditions, the current therapy does not address the basic defects.