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Subjects were instructed to abstain from brushing for a 12-hour period before the baseline visit.
In addition to the baseline visit, follow-up visits are scheduled at 6, 18, 36 and 54 months after baseline.
Data were also collected from the visit prior to the baseline visit (visit −1) and from two serial visits after the baseline visit (visits +1 and +2).
For the non-exposed patients, the baseline visit was the closest visit to July 2010.
Demographics, medical history, physical exam, headache features, and headache treatment history were recorded at the baseline visit (week 0).
In the event of retinal involvement, we performed fluorescein angiography within the first week of the baseline visit.
At the baseline visit, patients are screened for inclusion criteria, provide informed consent, and receive their first treatment with onabotulinumtoxinA.
Covariates from the baseline visit were used.
Fasting venous blood samples were obtained at the baseline visit to measure serum biomarkers.
CRP and fibrinogen measurements were not measured at the baseline visit.
A similar protocol was used at the baseline visit of CHS.
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