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However, one of the main limitations in using protein-protein interactions for function prediction is the availability of interaction data, especially for Mollicutes.
One of the main limitations in using protein-protein interactions for function prediction is the availability of interaction data, especially if one wishes to work with Mollicutes.
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Proteins function through their interactions, and the availability of protein interaction networks could help in understanding cellular processes.
Fortunately, a plethora of recent developments in biological network community, especially the availability of genetic interaction networks, make it possible to construct informative priors of complex interactions between genotypes, which can substantially reduce the complexity and increase the statistical power of GWA inference.
However, such an investigation is currently limited by the availability of complete interaction data.
Currently, the availability of protein protein interaction data for A. thaliana is limited in comparison with other model organisms (Stark et al. 2011).
We show that the stability of fibrils depends on both sequence and the symmetry because these factors determine the availability of favorable interactions between the peptide strands within a sheet and in intersheet packing.
With current initiatives in pathway and network curation [ 3],[ 4],[ 28] the availability of directed interactions is expected to grow.
Still, owing to the constraints in the gene annotation in the regions selected, availability of interaction data and that of ascertainment bias there is a possibility that a few plausible disease candidates would have missed out during the screening process.
The availability of high-quality interaction data from other species will thus help to clarify the architecture and evolution of PINs in greater detail.
These genomes vary greatly in the availability of annotations and interaction data.
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