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Treatment of Candida infections in general and C. albicans in particular is limited to the availability of classes and number of antifungal drugs.
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The availability of Class III sequences from other eutherian and marsupial species permits a multiple species analysis to be performed, adding power to the comparative analysis.
Even less evaluation is currently available on the multiple permutations that the availability of six classes of oral hypoglycemic agents may generate.
With the availability of several classes of drugs, HIV-1 infection has become a manageable disease for a majority of populations with the access to treatment.
Despite the availability of various classes of antidiabetes agents, nearly half of patients fail to achieve recommended glycemic targets [ 6, 7].
Invasive fungal infections are very severe infections associated with high mortality rates, despite the availability of new classes of antifungal agents.
Thrombotic disorders remain the leading cause of death in the Western world despite the availability of numerous classes of anticoagulants, such as vitamin K antagonists (VKAs), heparin derivatives and direct thrombin inhibitors [ 1].
The availability of core classes that represent modifications, peak annotations and chemical entities in a proteomics context, makes JPL the ideal framework to compute physicochemical properties, such as isoelectric point (pI), retention time (RT) and gravy index.
In the last years, the management of metastatic colorectal cancer (mCRC) has been relevantly changed by the availability of two classes of biological drugs: the anti-vascular endothelial growth factor (VEGF), bevacizumab (BV) and the anti-epidermal growth factor receptor (EGFR), cetuximab and panitumumab (Labianca et al, 2010).
The availability of different classes of drugs for chronic viral infections with differing targets within the relatively simple life cycle of these viruses has resulted in the development of simple semi-mechanistic models representing the life cycle of pathogens and/or their location in the host.
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