In Figure 5, we compare the extent of Qrr dosage compensation in the wild-type (black bars), the Δ hapR strain lacking the HapR-Qrr feedback loop (white bars), the luxO AUCC strain, which lacks the LuxO-Qrr feedback loop (grey bars), and the Δ hapR, luxO AUCC double mutant, which lacks both feedback loops (striped bars).
The luxO AUCC mutation partially eliminates dosage compensation for each qrr gene (compare grey bars with black bars), showing that indeed the LuxO-Qrr feedback loop contributes to Qrr dosage compensation.
The similar AUCC-normalized major elemental distributions and strong correlation of the major elemental compositions between the loess-paleosol sequences indicate that they may have originated predominantly from a similar loess source.
We did observe more variability than anticipated for the primary outcome AUCC.
For the evaluation of the model performance, several enrichment descriptors were calculated for each model: area under the accumulation curve (AUCc) [ 60], enrichment factor (EF) [ 61], robust initial enhancement (RIE) [ 62] and Boltzmann-enhanced discrimination of ROC (BEDROC) [ 48].
The levels of fasting C-peptide, Cmax, and AUCC in the patients without prior DKA were increased significantly 1 month after treatment and remained at a high level during the following 24 months.
A FS-MMTT was performed in a subset of subjects in the main study (∼50% of total subjects at selected sites) for measures of βCF including the ratio of C-peptide area under the concentration-time curve (AUCC) to glucose AUC (AUCG).
This trend is not unique to the U.S. A recent study by the Association of Universities and Colleges of Canada (AUCC) [3] showed that the average age of Canadian university professors increased from 42 to 49 between 1976 and 1998 and has been stable since.
Furthermore, the AUC of SN-38 per cycle (AUCc) was estimated by multiplying the AUC of SN-38 by the number of courses per cycle (× 2, × 4 and × 3 for arms A, B and C, respectively).
