Exact(4)
This method is not restricted by the array coverage or probe performance and thus allows a real genome-wide analysis.
Effectively, this means that for 78% of the targeted sequences on the array, coverage was sufficient (>20 × ) to detect any variants that were present.
The array coverage is based on 50-75mer probes with approximately 100 bp spacing, depending on the sequence composition of the region.
However, a sharp peak was observed in the simulated data at 15× coverage, whereas the array coverage data was more evenly distributed, likely due to the efficiency of the array capture.
Similar(4)
The CpG array coverage also extends into gene bodies, downstream gene locations, and currently uncharacterized chromosomal regions.
CMA V4 also failed to identify one marker chromosome, but this could be due to the limited array coverage.
We have also extended this study and have defined a more stringent core gene set compared to those previously published due to the comprehensive array coverage.
31 Marker chromosomes may also be missed, depending on the size, marker composition, and array coverage of the specific chromosomal region present on the marker.
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