Regulatory agencies, namely the United States Food and Drug Administration FDAandand the European Medicines Agency (EMA), have developed guidance documents concerning the appropriate development, validation, and use of PRO instruments in clinical trials [ 1, 2].
Lack of such information may hinder our understanding of the driving forces behind the accelerated obesity epidemic in the currently developing countries, which is important for the appropriate development of prevention strategies.
Having standardized methods will allow for easy comparison of results across studies and the appropriate development of biomarkers and their application to future drug development.
Finally, we discuss future directions and challenges for the appropriate development of biomarkers to evaluate product bioactivity and treatment efficacy.
The appropriate development and study of SDDS require that useful and biorelevant supersaturation and precipitation assays are available.
Later, Mr. Ward designed resort buildings in Acapulco and Barbados and the Mill Reef Club in Antigua; he wrote and lectured on the appropriate development for Caribbean destinations and promoted low-scale buildings in local materials.
