The application of approaches that consider the ionized state of the molecule might improve predictions of earthworm BCFs for pharmaceuticals.
We selected 11 approaches on the basis of 1) literature on the application of approaches to improving patient logistics in healthcare (see Additional file 1: survey) and, 2) the authors' expertise and the validation of five independent experts.
Two numerical examples show the application of the approach.
We illustrate the application of the approach using the example of a German medium-sized company.
In the application of this approach, the dynamical occlusion area cannot be applied without unintended touches.
Several examples are presented to demonstrate the application of the approach.
A separate numerical molding was also performed to evaluate the application of the approach developed.
However, the application of this approach is hindered by the following considerations.
Further evaluations will target the application of our approach in industrial settings.
The application of the approach was demonstrated using a subset of sample data from a real-world project.
