Exact(8)
A new theoretical analysis now demonstrates that hybrid-zone dynamics provide a counterintuitive explanation for how a new chromosomal sex-determination system can evolve and spread across the landscape, displacing the ancestral system, even though it would be eliminated by natural selection in a single isolated population.
The alternative interpretation posed was that the condition in N. scintillans was a derived state in this lineage: "The ancestral system may have had two genes, which fused in Noctiluca".
We assume that the ancestral system is controlled by polymorphism at a single sex-determining locus.
In what follows we seek to demonstrate selective advantage at each step, and, in line with the Continuity Principle, a continuous pathway where information is preserved from the ancestral system to the present.
This is an interesting study addressing an important question in developmental biology, namely how do DV patterning mechanisms in different animals relate and what was the ancestral system like.
Given that Cas5 and Cas6 are structurally similar and considering that Cas5 probably substitutes for Cas6 in subtype I-C, the ancestral system could have contained only one protein representing these two families.
Given ancestral male and female expression levels S ^ DM and S ^ DF, respectively, we set θ = (S ^ DM + S ^ DF ) / 2. In the ancestral system, we assume that there are no regulatory interactions controlling the D locus.
All reviewers agreed that this is an interesting study addressing an important question in developmental biology, namely how do DV patterning mechanisms in different animals relate and what was the ancestral system like.
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