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This data set also includes chimpanzee nucleotide information for each allele set when available; thus, we could determine which allele was the ancestral one based on our previous study [ 4].
It has previously been suggested that such an element is the ancestral one [ 14].
In HsInv0030, the Inv orientation is the ancestral one and is the major allele [ 11].
Alternatively, the ancestral one may become specialized to one sex, whereas the new duplicate becomes biased to the other sex.
In our previous work, the same reference sequence, the ancestral one, was used for each time-step.
Obviously, the minor allele −31T can significantly increase TBP affinity for the IL1B promoter relative to the ancestral one, −31C.
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To conclude, we show that each hydrophobic domain of TPCs is capable of insertion and forming oligomers, probably reflective of the ancestral one-repeat channel from which it evolved.
However, it was not possible to determine which sequences were the ancestral ones.
Above observations suggest the idea of gain of a target site unrelated to the ancestral ones of the miRNA, a mechanism that is not reported yet.
Most of the haplotypes found in the crater lakes were only a few mutations apart from the ancestral ones, providing evidence that these populations have diverged rather recently.
The unequal location of the modes can still indicate the remnants of a founder effect, where the newly rearranged alleles originate from the ancestral ones and form a distribution around the size of the ancestral allele.
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