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However, the analysis plans were also prespecified, without prior knowledge of the number of studies and specifics of the outcomes.
WR is the study statistician and has been involved in study design, the development of the analysis plans and the development and review of the manuscript.
JH and IJ worked on the data analysis and all authors were involved in the analysis plans and interpretation of data and results.
We compared the analysis plans from the main paper with the plan reported in the registry, protocol, or design paper for 60 trials (the plan was unclear for one published trial).
JK provided key programming support for development and management of all the databases and quality control, and participated in study meetings and development of the analysis plans during the first three years of the study.
In order to safeguard the integrity of the trial and avoid operational bias following an unblinded interim precautions need to be put in place to limit access to both the results and, even, the analysis plans.
Similar(52)
Preliminary analysis of the planned cohort study outcomes will be conducted to validate the analysis plan.
AF participated in collecting the data, developing the analysis plan, and conducting the data analysis.
Susan M participated in collecting the data, developing the analysis plan, and conducting the data analysis.
RA participated in collecting the data, developing the analysis plan, and conducting the data analysis.
Suki M participated in collecting the data, developing the analysis plan, and conducting the data analysis.
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