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This was mostly commonly an issue in regions where English is not commonly used in communication, e.g. South American countries in the AMRO region and Far-Eastern countries in the WPRO region.
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Finally, nine ERCC6 (tag) SNPs were genotyped in the AMRO-NL study population.
The AMRO-NL study population consisted of 375 unrelated AMD patients and 199 controls.
In addition, the AMRO-NL study revealed no significant association for 9 other variants spanning ERCC6.
In the AMRO-NL study, 331 unrelated AMD patients and 170 controls were genotyped for rs3793784.
The potential association of the SNPs with early and late AMD was analyzed in the AMRO-NL cohort.
Next, nine other ERCC6 (tag) SNPs were genotyped in 375 cases and 199 controls from the AMRO-NL study population.
In the AMRO-NL case-control study, association between the rs3793784 SNP and AMD was not found.
For the Rotterdam Study and the AMRO-NL study population, ORs were adjusted for age and sex.
In contrast, analysis of the AMRO-NL study showed no significantly increased disease OR for persons carrying potential ERCC6 risk alleles.
To determine the risk for the general Dutch population, we combined data from the Rotterdam Study and the AMRO-NL study population.
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