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At the research priority setting stage of a translational research project, the amount of developmental uncertainty surrounding the conceived product concepts is usually still enormous.
In an attempt to better understand the effects of exposure on development and to predict the amount of developmental delay, we developed a linear regression-based method for computing a Predicted Age (PA) for comparison purposes based on the expression level of developmentally-regulated genes and the time of harvest (see Methods).
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In addition, dystrophic changes in the CXMDJ diaphragm not only markedly altered the expression of fast and slow type MHCs but also decreased the amount of the developmental (embryonic and/or neonatal) MHC with growth, unlike affected TC muscle.
Across developmental periods there were significant effects of the psychiatric status [F(12,642) = 3.2, P < 0.001]: the post hoc tests showed that patients with personality disorders (P < 0.001) and with alcohol-related disorders (P < 0.01) reported a highly significant increase of the amount of neglect experiences across developmental periods as compared to the controls.
There will be the need for a considerable amount of developmental work before feasible mechanisms can be proposed.
The early post-natal mouse retina displays a measurable amount of developmental photoreceptor cell death, seen also here by the TUNEL assay in wt specimens (Supplementary Figure 1A).
There was not a higher amount of developmental and sporulation genes in the conidium that would be indicative of deposition of mRNAs during the process of asexual sporulation.
There was an increase of the amount of reported neglect experiences across developmental periods [F 3,642) = 91.5, P < 0.001].
To more accurately determine pectin DE%, we measured HG content as uronic acid, and methyl-ester content as the amount of methanol released, at the developmental stages described in Figure 1B.
Although it is clear that reducing the amount of EYA1 product leads to developmental defects (Schlosser et al., 2008; Zou et al., 2008), the possibility that these mutations also act in a dominant-negative fashion remains an open question.
The amount of false-positive cases having another developmental disorder justifies the need to examine developmental trajectories, to gain insight into which early signs are specific for ASD [ 71].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com