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Following randomisation the relevant pharmacy will be informed of the allocation (treatment A or B) by automatically generated email.
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Neither the participants nor the family practitioners or physiotherapists who delivered the intervention were blinded to the allocation of treatment.
The patients were blinded to the allocation of treatment and the assessor during follow up was blinded to the treatment.
A central composite design was used as an experimental design for the allocation of treatment combinations.
A central composite rotatable design was used as an experimental design for the analysis of the allocation of treatment combinations.
A central composite design was used as an experimental design for the analysis of the allocation of treatment combination.
The allocation to treatment was concealed until study entry.
The allocation to treatment conditions was not blinded.
Both the research physiotherapists and the principle investigator remain blinded for the allocation of treatment.
Four out of the 8 studies used satisfactory methods to conceal the allocation of treatment.
The allocation of treatment was managed by a centralized telerandomization system.
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