Sentence examples for the alloc from inspiring English sources

The alloc group bears a vinyl group that can weakly participate in hydrogel cross-linking, but with a low tendency for free radical propagation.

The lysine residue in 9 was coupled as described above for aminocaproic acid prior to the removal of the alloc group.

In addition, following Pd(0) cleavage of the alloc group, the liberated ε-amino group was coupled to aminocaproic acid prior to conjugating biotin.

Similar effects of the alloc caging were also observed with the related A2780 cDDP cell line (IC50 [ ©3] ≈ 5.1 μM, IC50 [ 3] ≈ 0.9, IC50[cisplatin] ≈ 0.8).

Because the alloc group is not acid or base labile, it can be easily incorporated into the peptide sequences using normal fluorenylmethyloxycarbonyl (Fmoc) synthesis methods.

Installation of the alloc protecting groups in the aza-pentamidine 3 was readily accomplished by reaction with allyl chloroformate in the presence of NaOH in H2O/THF (85% yield).

Removal of the Alloc-protecting group was achieved under argon atmosphere in anhydride CH2Cl2 in the presence of the scavenger phenylsilane (10 eq).

After some experimentation, the Alloc-group was found to be best-suited for our approach.

The lower DNA affinity of the alloc-protected ©3 with respect to 3 can be attributed to the loss of the electrostatic and hydrogen bonding interactions of the amidinium groups in the caged derivative.

Fluorescence microscopy (excitation filter 360 370 nm/emission filter 420 nm) showed blue staining of the whole cell, indicating that the alloc-protected DAPI (©4) is evenly distributed in the cells (Fig. 7a).

The use of lithium acylphosphinate (LAP) as a photoinitiator, which has increased rates of initiation and polymerization relative to other water-soluble photoinitiators, allows the rapid reaction of the alloc-modified peptides with the multiarm PEG thiol to form hydrogels under cytocompatible doses of long wavelength ultraviolet (UV) light (10 mW cm 2, 365 nm).