Sentence examples for the alk from inspiring English sources

In addition, the ALK-derived 36-aa peptide (P36) enhanced the cytotoxic effect of the ALK kinase inhibitor crizotinib in ALK-positive ALCL and neuroblastoma cell lines.

In this scenario, phosphorylation of ALK is independent of the ALK extracellular region, since a membrane-bound construct containing the ALK intracellular region is phosphorylated as effectively as the full-length protein [ 61].

Since all partner protein genes at the 5′ end of the ALK fusion gene are widely expressed, the ALK fusion protein is constitutively expressed under the control of the 5′ end partner protein gene promoter in ALK+ ALCL.

Twenty-four (39%) of the ALK + patients had B symptoms compared with 14 (41%) of the ALK- cases.

These fusion partner proteins of ALK share several common characteristics: (i) the transcription of the fusion protein is driven via the promoter of the ALK partner protein; (ii) the localization of the fusion protein is determined by the ALK partner protein and; (iii) oligomerization via the ALK partner protein induces autophosphorylation and thereby activation of the ALK kinase domain.

Scientists said the ALK gene aberration tends to be more frequent in younger patients and nonsmokers.

The ALK gene status of NSCLC with atypical CT features should also be investigated.

Both compounds showed strong antiproliferative activity against the ALK-addictive H3122 cells (11 vs 13 nM).

The alk-Ti3C2 modified electrode exhibited significantly improved electrochemical response in comparison with the Ti3C2 modified electrode due to the unique morphology and surface chemistry characteristics.

The ALK-inhibitor TAE-684 (CID16038120) was synthesized in N. Gray's laboratory [10].

Similarly, the coculture-induced association between occludin and zo-1 was reversed with addition of the ALK-5 inhibitor.