Exact(8)
The efficacy of sub-chronic administration of zolpidem to alter sleep architecture was enhanced when the administration regimen was repeated following a 7-day hiatus.
Given the same daily dosage, we wondered whether the administration regimen was a factor to affect the experimental result.
If pharmacologic stress with adenosine is used, the administration regimen will be comparable with the CMR protocol.
Ideally, breakpoints specific to animal species, disease, pathogen, drug, and the administration regimen (dose, route, duration, and frequency) should be used for the most clinically valid interpretations.
To further improve the administration regimen, we evaluated whether extending the recovery period in between dosing would improve tolerability without affecting antitumor effect.
Because response to treatment is related to both the dose and the administration regimen of drugs, non-compliance with treatment may reduce its benefits [ 10] and may also reduce its effectiveness [ 11, 12].
Similar(52)
However, we have observed that there is little uniformity in the administration regimens of potential treatments between the designs, which hinders congruence in the development of single treatment strategies to reduce both impulsive behavior and drug choice.
The currently available formulations of mesalazine have a number of practical differences, including the administration regimens for which they are indicated.
The administration regimens involving aspirin in utero and during weaning alone or in combination prior to curcumin had no detrimental effect on propensity towards gastrointestinal bleeding, as reflected by the haematocrit (results not shown), nor did they cause gastric erosion and loss of mucosal integrity, as adjudged by macroscopic inspection.
EtOH modifies many of the effects of MDMA, and studies suggest that the interaction between the two drugs depends on the dose, administration regimen and ambient temperature in question [ 18, 19].
The early administration regimen will be referred to in the following as ' in utero and during weaning', the late regime as 'postweaning'postweaning
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