Sentence examples for the additional alterations from inspiring English sources

The clinical utility or actionability of the additional alterations detected by WES/WGS compared with targeted sequencing involving cancer-specific gene panels for treatment selection or matching patients to clinical trials remains to be determined.

The different sensitivity against PRL-3 targeting as shown in the present study may imply the additional alterations attenuating the dependence of PRL-3 signetworksetwonks on cancer cells.

It is therefore likely that, like for the additional alterations such as trisomy 8 and isochromosome 17q, the observed EVI1 overexpression contributes to the aggressive phenotype of the blastic CML phase.

The additional alterations of gene expression between cancer and normal cells include the anti-apoptotic oncogenes that encode Bcl-2 and Bcl-XL, and genes that encode the peripheral benzodiazepin receptor (PBR), the PBR-associated protein Prax-1, and mitochondrial creatine kinase.

Changes in this neuroendocrine response to stressors, with the additional alterations in between behaviours related to stress such as increased smoking, increased alcohol consumption and physical inactivity [ 29] might explain the association between allostatic load and an increased risk of CVD, specifically coronary heart disease (CHD).

Alternatively, these additional alterations might have occurred at the distant site of metastasis, and therefore represent de novo mutations that were not present in the primary tumors.

In fact, these additional alterations appeared to improve viral fitness, because the late harvest progenies had shorter latency periods than the early harvest ones (Fig. 2).

An alteration saw the addition of two chimneys and additional alterations to the window and door openings on the northeast and southwest sides of the house.

Attributes are placed within the tag itself, making additional alterations to the "element content" between the start and end tag.

To evaluate the presence of additional alterations in these genes as a consequence of the ENU mutagenesis, we sequenced their genetic loci in the AB/TL wt strain in our facility (used to outcross the mutant) and in two families of cxcr3.2 +/+ and cxcr3.2−/− fish.

That mutation to the gene encoding the TET2 enzyme is only one of many mechanisms that can cause its dysfunction [ 54] raises the possibility that additional alterations not detectable by genetic sequencing may, too, inhibit the function of this critical regulator of the epigenome and contribute to melanoma virulence.