Without the additional adjustment the adjusted odds ratios for ≤ 2 or > 2 prescriptions were 0.97 (95% CI: 0.77, 1.2) and 0.83 (95% CI: 0.61, 1.1), respectively.
With the repeat analysis of the risk of dementia with ARB exposure in the initial 12 months following the index date with the additional adjustment for stroke, the adjusted hazard ratio for dementia was 0.61 (95% CI 0.51 0.73).
Further adjustment for caloric intake had little impact on the age-, sex-, and percent body fat adjusted associations between PA and fasting glucose, 2-h glucose, fasting insulin, 2-h insulin, AIRg, SI, and DI; the additional adjustment resulted in <10% change in the corresponding regression coefficients, with adjusted P values of 0.098, 0.017, 0.0003, 0.016, 0.21, 0.16, and 0.019, respectively.
After the additional adjustment for discontinuation of fenofibrate therapy, efficacy estimates moderately improved to a 15% reduction in cardiovascular events (P = 0.008) and a 16% reduction in CHD events (P = 0.06).
It was found that, as compared to the equilibrated S1 conformation from B-S1 or reconstructed "E-S1" structure (1st or 2nd set of bars from the left), the additional adjustment of residue W1 or D89 orientation tuned to that of S2 did not induce conformational change of S1 Lec domain (RMSD <3.0 Å, 3rd and 6th solid bars).
The additional adjustment for inflammatory markers led to an even greater attenuation of the association.
The additional adjustment for those variables did not change the observed associations (data not shown).
This nonsignificant association was virtually unchanged after additional adjustment for traditional diabetes risk factors and further attenuated with the additional adjustment for BMI.
The additional adjustment for self-reported physical activity did not change the detected findings (Additional file 1: Table S1).
The additional adjustment for these potentially confounding or mediating variables slightly attenuated the risk associated with depression.
