Sentence examples for the activity of chip from inspiring English sources

On the other hand, the co-chaperone HspBP1 inhibits the activity of CHIP and thereby attenuates antigen sequestration.

The activity of CHIP with regard to DALIS formation is apparently controlled by HspBP1 in professional antigen presenting cells.

Ablation or a complete absence of HspBP1 in BMDCs resulted in increased DALIS formation, illustrating that the co-chaperone restricts the activity of CHIP in professional antigen presenting cells.

The activity of CHIP has been shown to be regulated by members of the BAG family, including BAG1 [23] and BAG2 [33], [41], [41] which each associate with CHIP and modulate CHIP E3 ubiquitin ligase function.

The activity of CHIP is also regulated through posttranslational modifications [ 44].

Recent studies have highlighted varied regulatory mechanisms operating on the activity of CHIP which is crucial for cellular homeostasis.

Moreover, the ubiquitin ligase activity of CHIP in these cells is under control of the CHIP-inhibitor HspBP1.

These results indicate that both the chaperone interaction and the ubiquitin ligase activity of CHIP are required for CHIP-mediated degradation of LRRK2 protein.

However, the ubiquitin ligase activity of CHIP on p53 is likely under tight regulation but the mechanics behind this control remain unclear.

Under these conditions, IGF-1 (insulin-like growth factor 1) induction or MEK5 α overexpression results in a specific and obligatory association between ERK5 and CHIP; this increases the E3 ligase activity of CHIP, through a hitherto unknown mechanism, subsequently degrading ICER and inhibiting apoptosis) [ 55].

But, when CHIP was expressed in HEK-APP cell, the DNA-binding activity of p53 was restored due to chaperone activity of CHIP.