Solid form screening, the activity of generating and analysing different solid forms of an active pharmaceutical ingredient (API), has become an essential part of drug development.
The activity of sAA was analysed with a kinetic colorimetric test using assay kits from Roche (Roche 11555685 alpha-Amylase Liquid acc, Roche, Basel, Switzerland) and an automatic analyser (Biotek Instruments, Lucern, Switzerland) with the software KC4 (Roche).
The activity of SaTenA was analysed in 100 µl 100 mM Tris-HCl, pH 7.5, containing either 1 mM thiamine or 1 mM TMP or 1 mM TPP and incubated for 30 min at 37°C.
In regard to possible effects exerted by D609 on the activity of other enzymes, previous analyses of reaction mixtures showed that D609 did not directly inhibit PLD, phosphatidylinositol-specific phospholipase C (PI-PLC), phospholipase A2 [ 22], or sphingomyelinase [ 24].
Thus, the sensitivity to DM4 and AVE9633, the expression of CD33 and the activity of P-gp were analysed in cells from 25 AML patients.
Different potentially relevant cellular parameters for the activity of combined drugs were analysed on the human colon cancer cell line WiDr in clinically relevant conditions of drug exposure.
To further analyse the activity of the variant 4C7, we determined caspase activation in OVCAR-3 cells using FRET and fluorescent probes.
This study analyses the activity of 95 antisera raised in rabbits against human leukaemic myeloblasts.
The Electronic Frontier Foundation EFFF) publishes Who Has Your Back? report annually, analysing the activity of companies ordered to hand over sensitive user data in response to US government requests.
He then analysed the activity of their genes, as measured by the production of a substance called messenger RNA.
We analysed the activity of four pairs of 'teacher-designers' during a design task.
