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Interestingly, Tregs from untreated NOD mice had much greater inhibitory activity at the activation phase compared to that at the effector phase of CD8 8.3 T cell differentiation.
If Treg cells were isolated from NOD mice that have been treated with IL-2/anti-IL-2 mAb complexes, their inhibitory activity during the activation phase did not improve dramatically.
As the activation phase of the canonical NF-kB activity is determined by negative feedback through newly synthesized IκBα and IκBδ (as well as molecules such as A20), the ability of LTβR signaling to somehow overcome the observed reduction of canonical NF-kB activity, is also an interesting observation.
Since a reduction in mGluR6 activity underlies the light-evoked responses in ON-BCs (compared to an increase in rhodopsin's activity for phototransduction), G protein deactivation drives the activation phase of the response and RGS proteins influence its slope.
The baseline production rate of the activator does affect the time for the recovery phase, as well as the activation phase (Fig. 6).
Second, we cultured retinal explants during the activation phase in the presence of GS-GFP lentivirus [23] for lineage tracing of the activated Müller cells.
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We acknowledge that the analysis of the "activation" phases of the GIRK channel responses could be complicated.
IDO may exhibit its immune inhibitory functions both in the activation phases (in the draining lymph node) as well as in the effector phases (at the site of the tumor).
The expression of α-lactalbumin has been used to determine whether a mammary gland has progressed from the first stage of lactogenesis known as the secretory initiation phase to the second stage, the secretory activation phase [12].
Nearing parturition, alveolar tight junctions close and milk and colostrum proteins move into the alveolar lumen, in preparation for active milk secretion post-partum, which marks the onset of the secretory activation phase [ 8].
However, some MKK7 proteins still need to be active at later time points to induce the second activation phase of JNK.
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