Sentence examples for the activation and activity of from inspiring English sources
Fibrogenesis and tumor progression are regulated in part through the activation and activity of myofibroblasts.
We found that baicalin significantly inhibited the activation and activity of caspase-3.
Overexpression of Grp78 in hepatocellular carcinoma cells enhanced the activation and activity of FAK which negatively regulated Rock kinase activity by promoting the phosphorylation of p190RhoGAP.
To confirm the role of Grp78 in the activation and activity of FAK, Grp78 level in Grp78 overexpressing cells was knockdown by siRNA transfection, pY397 and p Y576/577 levels were examined.
Thus, inhibiting caspase-2 by either protein knock-down or pharmacological inhibition reveals that TRIM16 requires the activation and activity of caspase-2 to function as an apoptotic molecule.
This study was designed to investigate the expression, activation and activity of matrix metalloproteinase-2 (MMP-2) in the heart of broiler chickens reared in cold conditions and fed with copper-methionine supplement at different levels.
This correlates closely with the reduced activation and activity of ERK2 MAPK that is required for progression to the S phase of the cell cycle, thus explaining altered IL-2 secretion and proliferative hyporesponsiveness.
We found that Grp78 siRNA knockdown in Grp78 overexpressing cells significantly decreased pY397 and p Y576/577 levels of FAK, indicating that the enhanced activation and activity of FAK in Grp78 overexpressing cells was caused by Grp78 itself (Fig. 4B).
In addition, the recently characterised MMP inhibitor, RECK (reversion inducing cysteine-rich protein with Kazal motifs) can exert effects on the synthesis, activation and activity of several MMPs (Oh et al, 2001; Sasahara et al, 2002).
HAI-1 inhibits HGF activator, thereby inhibiting the activation and subsequent activity of HGF.
Our results demonstrate for the first time that leptin attenuates the activation and transcriptional activity of NF-κB by reducing the acetylation of the p65 subunit in a SIRT1-dependent manner.
