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CGP 46381-treated rats took longer to learn the location of the escape platform and travelled a greater distance over the acquisition trials.
The same results were found for speed during the acquisition trials in the MWM task.
No difference of swim speed was found between WT and cKO mice throughout the acquisition trials (data not shown).
Data from the acquisition trials of Morris water maze were analyzed by a two-way mixed design ANOVA (strain x test day) separately for two different age groups.
Furthermore, the SFR mice used the search strategy "Serial" significantly faster than the MS mice in the acquisition trials, but this was not true in the reversal trials.
Table 1 shows a summary of the PC responses to the CS and the changes in these responses after the acquisition trials, and Figure 2 shows actual examples of simultaneous recordings of PCs and heartbeats.
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In the passive avoidance test, there was no significant difference in the latency time among groups in the acquisition trial (Fig. 1f).
The injection of saline or tetracaine was applied 5 min before or 5, 90, and 360 min after the acquisition trial and 5 min before the retention tests.
During the acquisition trial, each mouse was placed in the illuminated chamber, the guillotine door was opened after 10 s and the initial latency to enter the dark compartment was recorded.
The time that the rats spent in overt exploration of the to-be-remembered objects during the acquisition trial was not affected, suggesting that the drug may have impaired processes of memory formation independently of interference with attention.
Parasagittal cerebellar slices (200 µm thick) were prepared 24 h after the acquisition trial following standard procedures [15], [17].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com