Cells lose adhesion with the loss of tight junctional proteins, like claudins, thus allowing the acquisition of migratory capabilities [44].
Genomic instability is a hallmark of cancer that leads to an increase in genetic alterations, thus enabling the acquisition of additional capabilities required for tumorigenesis and progression.
Malignant transformation is dependent on the acquisition of specific capabilities, from uncontrolled growth, to escape from apoptosis, to metastatic invasion (Hanahan and Weinberg, 2000), typically obtained through mutations or genomic rearrangements.
Cancer metastasis is considered to develop in a step-wise fashion leading to the acquisition of new capabilities by tumor cells helping them to thrive and evade natural barriers [ 3].
Targeted therapeutic strategies based on an improved understanding of the molecular biology of malignancy have been applied to CRC with little success; however, recent insights linking deregulated miRNA expression to malignant change and to the acquisition of metastatic capabilities have brought renewed optimism.
These efforts are crucial to augmenting technology transfer and expediting the acquisition of technological capability.
The fundamental issue of such a revolution is the effort towards the fabrication of innovative nano-structured functional materials and, in particular, the acquisition of the capability to control all their characteristics (electrical, optical, mechanical, etc).
In general, the new "Defense Strategic Review" to be outlined Thursday will try to define American national security interests in what officials said would be more realistic, narrow terms — to allow the acquisition of required military capabilities with a reduced budget.
It would appear that the acquisition of collagen binding capabilities occurred in the chordate lineage after the divergence of ascidians.
In the ten hallmarks of cancer, genome instability is an enabling characteristic that has close association with the acquisition of other hallmark capabilities [ 2].
