Sentence examples for the accessible pool from inspiring English sources

The membrane lipid composition determines how much cholesterol can be complexed within the inaccessible pool, and cholesterol in excess of that threshold partitions into the accessible pool.

The best model to explain rituximab PK is a two-compartment model, with first-order distribution kinetics between the peripheral circulation and the accessible pool of CD20-binding domains, with mean half-lives of approximately 1.3 and 19 days for distribution and elimination, respectively.

As shown in Figure 10, the level of buffered or accessible Zn2+ in the ER and Golgi of HeLa cells is approximately 100-fold lower than in the cytosol, and the accessible pool is lower still in the matrix of mitochondria.

The vast majority of the cellular Zn2+ pool is bound to proteins, enzymes, metabolites, and other low molecular weight ligands such that the labile or accessible pool of Zn2+ in the cell is in the picomolar range.

Using the conversion factor defined by Figure 3 and the I-PFO* binding value of the increase in the PFO-accessible pool (18 µg/mg), we estimate the SM-sequestered cholesterol pool to be 23 mole% of PM lipids.

Additional file 1: Table S13 shows that in some tissues the readily accessible pools are only a fraction (6 to 40%) of cellular non-heme iron.

Using the conversion factor defined by Figure 3 and the I-PFO* binding value of the increase in the PFO-accessible pool (9 µg/mg, Figure 4C), we estimate the SM-sequestered cholesterol pool in this experiment to be 12 mole% of PM lipids, which is somewhat lower than the 18% value calculated for Figure 3. 10.7554/eLiFigure82.008 Figure 4. Effect of LDL on SM-sequestered pool of PM cholesterol.

The ESM contains a readily accessible pool of AMPARs [ 19], and receptors have been shown to exchange between the ESM and the PSD under resting conditions [ 2, 28].

The first pool is the 'PFO-accessible pool' that binds I-PFO* when the membrane is in its native cholesterol-replete state.

Using this result, we can derive an approximate relationship between I-PFO* binding and the magnitude of the PFO-accessible pool: 1 µg/mg protein of I-PFO* binding corresponds to 1.3 mole% of PM cholesterol that is PFO-accessible.

We recently described a probe that measures an accessible pool of cholesterol in the PM (Das et al., 2013).