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The ability of CHIP to interact with HSP70 and function as a ubiquitin ligase places CHIP in a pivotal position in protein quality control [ 162] and makes CHIP a frequently analyzed protein in polyQ refolding and degradation.
This has limited the ability of chip makers to raise prices even though demand for high-end semiconductors has improved.
These results demonstrate the ability of CHIP to ubiquitinate LRRK2.
We demonstrate that BAG5 mitigates the ability of CHIP to reduce α-syn oligomerization and that non-ubiquitinylated α-syn has an increased propensity for oligomerization.
Consistent with this, we found that BAG5 inhibited CHIP-mediated ubiquitinylation of α-syn and mitigated the ability of CHIP to decrease levels of α-syn oligomers.
It has been proposed that the ability of CHIP to degrade potentially neurotoxic misfolded, damaged or mutated proteins might diminish with age [25].
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It said: "Water won't damage the ability of a chip to function".
Once in the computer, the picture can be incorporated into documents, placed into websites, e-mailed to friends or printed out at home using new, cheap colour printers.The most important thing that limits the quality of a digital camera is the ability of a chip called a charge-coupled device (CCD).
He is testing the ability of computer chips implanted in the brain to do just that.
I anticipate breakthroughs that will boost the ability of the chips and subsystems on a phone to perform optimally for far longer.
Researchers from Cambridge University and the Japanese electronics giant Hitachi sought to figure out how to duplicate the ability of standard chips to store data as 1's and 0's, but in less space.
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