Sentence examples for the NRAS from inspiring English sources

A majority of cutaneous melanomas show activating mutations in the NRAS or BRAF proto-oncogenes, components of the Ras-Raf-Mek-Erk signal transduction pathway.

The collaboration between the NRAs in United Republic of Tanzania is fertile ground for regulatory harmonisation process in the region.

Representatives from the NRAs requested WHO to share the report of the assessment that was the basis for the prequalification.

The NRAS gene codes for the NRAS protein.

Mutations in NRAS occur in 15 20 % of melanomas and result in constitutive activation of the NRAS protein and enhanced MAP kinase signaling [ 40– 40].

Here, the responsive T6 promoter drives expression of N-RAS61K and EGFP, the latter being separated from the NRAS gene by an IRES site.

Fine needle aspiration cytology of the lesion revealed a Q61R mutation in the NRAS gene and other molecular aberrations in addition to the BRAF mutation.

However, the NRAS mutation may be associated with sensitivity to MEK inhibitors [9].

The major NRAS mutations associated with melanoma are 'activating mutations' — they cause the NRAS protein to turn on and stay on.

Recently, it was demonstrated that early embryonic, post-zygotic somatic mutations in the NRAS gene are implicated in the development of NCM and childhood melanoma of the CNS [ 6, 7, 9].

These Third Package requirements establish an important mechanism to guarantee the independence and impartiality of the NRAs.