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Using binding information gained from the analysis of two glitazones docked in these pockets, we designed and synthesized a ligand (NL-1) that would preferentially bind to site 1.
In theory, for each unique FRT-like sequence, it should be possible to evolve a unique Flp variant that would preferentially recombine this sequence.
In other words, there seem to be no prominent 'highways' of HGT that would preferentially connect particular groups of archaea and bacteria.
Future studies will show whether recombinant target proteins, used in the current study, are able to induce critical feedback regulators that would preferentially expand IL-17 –producing immune cells [ 12].
A recent publication has also shown how the different ROS content of transformed and normal cells can be used to design therapies that would preferentially target transformed cells (Raj et al, 2011).
However, two distinct voltammetric features are not clearly resolved, regardless of the temperature, pH, or ionic strength (not shown), each of which could be a factor that would preferentially modulate one of the two cofactors' redox properties.
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In our study, at least two different mechanisms could explain the increase of AI at 11p15 and 11q23.3 after chemotherapy: a pre-existent undetectable small population of tumour cells bearing one AI could have been selected by the treatment that would have preferentially targeted the tumour cells without AI.
Though both PCL and P2VP homopolymers are soluble to at least 10 mg/mL in toluene, based on the prior studies of P2VP block copolymers and the Chan et al. study of PCL- b-P4VP, we expected that toluene would preferentially solvate PCL, such that P2VP would form the core of PCL- b-P2VP micelles assembled in toluene.
It is possible that cerebellar seeds could correlate with widespread regions of the cerebral cortex or that all would preferentially correlate with MOT.
This observed orientation preference for expansions is less well explained by the fork-reversal model, since the sequence that is expected to form a more stable pseudohairpin on the lagging-strand template is the CTG repeat that would be predicted to preferentially generate a CTG repeat pseudohairpin on the newly synthesized leading strand.
One indication that ATRX would preferentially target repetitive sequences comes from studies done in human ATR-X syndrome patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com