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Our current work supports that phage can extravasate to extracellular matrix and epithelial cells, determining upfront the peptides that would be efficacious systemic tumor-targeting agents.
Peptides alone, with or without targeting signals conjugated to them, will rarely pass the blood brain barrier, and not in any concentration that would be efficacious (Carman et al., 2011).
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A low coverage suggests that most of the genomic DNA in the sample has not been sequenced, but it is often difficult to estimate either the extent of the uncaptured diversity or the amount of additional sequencing that would be most efficacious.
The choice of target tissue affects the type of vector system that would be expected to be efficacious and profoundly affects the potential for host immune responses to negatively impact the therapy.
Handwashing has been efficacious in preventing influenza [ 16, 17] and SARS [ 9] and the vast majority of the respondents (94%) believed that it would be efficacious in preventing human-to-human avian influenza.
Based on the positive results of aripiprazole for both treatment-resistant depression and treatment-resistant PTSD, and on its unique pharmacology, we hypothesized that aripiprazole would be efficacious for treatment-resistant military-related PTSD with comorbid major depression.
Typically, infections are cleared by neutralizing antibodies, which suggests that a vaccine would be efficacious.
In previous trials, it has been observed that this dosage would be efficacious for both larger patients (>100 kg) but also safe in smaller patients (<50 kg) without adverse events[ 25].
Therefore, it is critical that controlled trials be undertaken with existing therapeutic agents or modalities where anecdotal evidence in patients with FXTAS, or controlled studies with related disorders, suggests that such approaches would be efficacious.
The high bioavailability of famciclovir (77%) and the rapid onset of viral replication in recurrent genital herpes suggested that this medication would be efficacious in an even shorter single-day treatment regimen.
As patients with Crohn's disease have a functional insensitivity to GH, the present study examined the possibility that rhIGF-1 would be efficacious in improving IGF-1 concentrations, as it does in children with GHIS.
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