These findings suggest that CAR will be altered differentially, contingent on the physiologic response of the athlete to the training load imposed on them.
One consequence of escape from XCI and incomplete dosage compensation is that there will be altered gene expression associated with X chromosome aneuploidies.
However, genetic or pharmacological manipulation of molecular signaling pathways does not, by itself, ensure that function will be altered because of physiological redundancy [ 38], even under conditions in which some other phenotypic change has been induced, including lifespan extension.
Experiments in haptic (Gandolfo et al., 1996; Patton et al., 2001; Shadmehr & Mussa-Ivaldi, 1994) and virtual-reality environments (Krakauer et al., 1999; Pine et al., 1996) have repeatedly shown that movement will be altered by changes in environment, and may remain altered for a short time after the original environment is restored ("motion aftereffect").
We postulate that TOI will be altered in the vascular bed when blood flow is decreased; the resultant acidosis in poorly perfused tissues may also further increase the dissociation of oxygen from haemoglobin and increase the portion of reduced haemoglobin detected with NIRS.
For example, if a gene does not show a change in transcript abundance but nevertheless interacts with a number of genes that show significant expression changes, it is likely that its functionality will be altered.
This taps into deep fears about "Frankenstein babies", parthenogenesis and asexual reproduction, and the anxiety that human procreation will be altered in some fundamental way – and one that marginalises men.
But the worry for all other government-bond markets is that investment terms will be altered retrospectively.
In housing it emerged that homelessness legislation will be altered to allow councils to find homeless families private rented accommodation rather than being put on a waiting list for a council house or housing association accommodation.
