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It is an analogue of cytosine, that when incorporated into DNA, irreversibly binds the methyltransferase enzymes as they attempt to methylate the cytosine analogue.
In particular, 5-aza-dC, a strong inducer of DNA de-methylation (global hypomethylation), is, an analogue of cytosine, that when incorporated into DNA, irreversibly binds the methyltransferase enzymes as they attempt to methylate the cytosine analogue.
Fragment-docking-oriented de novel design for both the catalytic site and the C phosphotyrosine binding site led to the discovery of novel scaffold and chemical easy N- 2,5-diethoxy-phenyl -methanesulfonamide based phosphotyrosiN- 2,5-diethoxy-phenyl -methanesulfonamideeas are high poteN- 2,5-diethoxy-phenyl -methanesulfonamideosiN- 2,5-diethoxy-phenyl -methanesulfonamide
Cuprizone is a neurotoxin that when incorporated into the feed of mice, induces specific and focal T cell-independent demyelination within the CNS, particularly in the corpus callosum [22], [23], [24].
The data show that mutating this amino acid region results in a factor Va molecule that when incorporated into prothrombinase produces an enzyme with an overall 10-fold decrease in its second-order rate constant.
Overall, the data demonstrate that elimination of amino acid region 680−709 from factor Va results in a cofactor molecule that when incorporated into prothrombinase produces an enzyme responsible for both delayed prothrombin activation and persistence of meizothrombin during activation of prothrombin.
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The structure property relationships gleaned from our study brings about new insight for the design and synthesis of new isoindigo-based molecular semiconductors that yield higher PCEs when incorporated in solar cells.
Moreover, it became evident that foamed bitumens perform better when incorporated into recycled asphalt mixtures.
It became clear that different types of Acacia gums when incorporated in SCPs gave different responses and should be used with complete understanding.
Since the boron doped tubes are hole doped this suggests that carbon nanotubes could be dilute magnetic semiconductors when incorporated into field effect transitor devices.
In vivo study enabled to demonstrate that BENZO and LIDO can be released in a prolonged fashion when incorporated into lipid carriers.
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CEO of Professional Science Editing for Scientists @ prosciediting.com