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Recently, some authors described the case of a patient with massive tophaceous gout that was concomitantly treated with 3 different ULTs, in particular allopurinol 600 mg/day, benzbromarone 100 mg/day, and 4 monthly rasburicase infusions that lead to the almost complete resolution of tophi before rasburicase withdrawal due to flushing and urticarial occurrence during the fifth infusion [ 100].
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[14] The most plausible explanation for these discrepant observations are the potent antiMAP agents that were concomitantly used in our patients.
To identify the clusters of genes that are concomitantly regulated by various LDLs, Hierarchical Clustering analysis [ 27] was applied.
We next compared patient groups on the basis of the number of MetS criteria that were concomitantly present.
The mixed disulfide, (GSTNB), that is concomitantly produced, is reduced by GSH reductase to recycle the GSH and produce more TNB.
We excluded from the analyses the ARI patients that were concomitantly positive for both influenza A and B or for two (or more) influenza A subtypes.
Two algorithms, Hierarchical Clustering analysis [ 27] and Self Organizing Map (SOM) [ 28] were used to identify the clusters of genes that are concomitantly regulated by various LDLs.
The mixed disulfide, GSTNB (between GSH and TNB) that is concomitantly produced, is reduced by GSH reductase to recycle the GSH and produce more TNB.
Cheng et al. used integrative genome-wide scans to identify genes that were concomitantly hypermethylated in mouse and human gastric cancer samples infected with H. pylori.
We checked that the stable [F]FDG uptake in treated tumours that were concomitantly decreasing in size was not due to partial volume effect (PVE) [ 33] and found that PVE alone could not explain our observations.
It is conceivable that intracellular processing of procollagen could be mediated by newly synthesized procollagen-processing enzymes that are concomitantly synthesized and transported with procollagen through the secretory pathway and activated by furin-like convertases before secretion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com