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The level of statistical significance (p = 1.6 × 10−4), however, does not achieve that typically required for genome-wide significance (Dudbridge and Gusnanto 2008), so it remains possible that the diabetes association is spurious.
While this initial optimisation step is time-consuming, in our experience, this process is essentially the same as that typically required for any new primer set to be used in conventional PCR.
Hence, the micromolar concentration of KAAD-cyc required to block SUM149 cell proliferation here is much higher than that typically required to inhibit Hh-pathway activity, suggesting a SMO-independent off-target inhibitory effect as has been suggested for its in vitro growth inhibitory effects on other cancer cell lines (Yauch et al, 2008; Zhang et al, 2008).
DSLRs previously cost inordinate gobs of cash that typically required the selling of organs and/or your first born.
Precisely adjusting the lacing all the way up to full lockdown was something that typically required a coach to do.
"Moderate" effects were less pronounced symptoms with no residual effects but that typically required treatment.
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That typically requires some vigilance from the outset, however.
The H-1B visa is intended for specialty occupations that typically require a college education.
Conventional farming may seem natural, says Dring, but among commercial operations use greenhouses or polytunnels that typically require artificial heating, many also use LEDs in addition to sunlight.
Drone strikes are more likely to take the form of discrete attacks than the concerted air campaigns that typically require fighter pilots.
Much of the vital correspondence that was once sent by mail is now handled over fax machines and e-mail, and by express-delivery services that typically require more information about senders than the postal system does.
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