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An inhibitor class was conceived that is selective for T. cruzi glucokinase (TcGlcK) using structure-based drug design involving glucosamine having a linker from the C2 amino that terminates with a hydrophobic group either being phenyl, p-hydroxyphenyl, or dioxobenzo[b]thiophenyl groups.
They are made of a hydrocarbon chain that terminates with a carboxylic acid group; this arrangement confers the molecule with a polar, hydrophilic end, and a nonpolar, hydrophobic end that is insoluble in water.
The section of a Foley catheter that is inserted into a bladder consists of a hollow, cylindrical rubber tube that terminates with a solid rubber tip.
On its tail is a prominent band of black fur that terminates with a white tuft that surrounds a naked, spurlike tip.
The packing structure of stationary pebbles is simulated by a filling process that terminates with the settling of the pebbles into a PBR.
[73] As shown in Figure 12b, residues between Thr28-Lys35 form a path beginning with hydrogen bonded residues Lys35 and Lys31, that terminates with two binding site residues Thr28 and Glu33.
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CHO cells expressing monoclonal antibodies that terminate with a C-terminal Gly residue are often partially α-amidated [ 5, 9].
The annealed nanoparticles that terminate with butyl and ethyl groups have core sizes of ∼14 and ∼17 nm with carbon shell thicknesses of ∼16 and ∼8 nm, respectively.
On the other hand, annealed nanoparticles that terminate with methyl groups have core sizes of 40 nm with a very thin carbon shell without uniform coverage of the core.
In contrast, transcription initiated at the CD40L promoter results in stable transcripts that terminate with a polyadenylation signal.
As a glycoprotein, fetuin-A carries two N-linked and three O-linked oligosaccharide chains that terminate with sialic acid residues, and can bind biogenic cationic ions (e.g., Ca2+) and other anti-inflammatory molecules (e.g., spermine) [35], [36].
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