Mr. Ollman said he understood, from clients of his who had bought or been offered pieces, that substitutions had been made in the Christie's sale, as pieces sold privately.
Preliminary SAR results indicated that substitutions on nitrogen are critical to the antitumor potency.
The "molecular clock" is not strictly clock-like, however it is regular enough that substitutions do relate to time.
These studies suggested that substitutions around the phenoxy ring of this scaffold can impart improved potency and selectivity for MEKK2.
A major limitation of conventional site-directed mutagenesis is that substitutions are restricted to the 20 naturally occurring amino acids.
The results also indicated that substitutions greater than 10% cause dramatic decline in all strength-related parameters of the concretes.
We demonstrate that substitutions of Cd and Ba in MgB2 show a higher calculated Tδ than MgB2 by more than 20 K.
Here we show that substitutions of glycine at 171 to K, F, I and Q also resulted in HBM-like activity in the presence of Wnt1 and Dkk1.
There are indications that substitutions may be occurring with the proximity to playgrounds, which are watered more regularly, becoming significant with increasing severity of water restrictions.
Be warned, however, that substitutions are not allowed, and good luck finding ketchup (they will, however, cook the meat to the temperature of your choice).
For instance, it was found that substitutions of two charged amino acid residues on the surface of α-lytic protease to hydrophobic residues improved protease stability in presence of hydrophilic solvents (Martinez and Arnold 1991).
