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Gag-Pol regions that were processed rapidly to produce p24CA resulted in high-level replication by recombinant viruses, while slow-processing Gag-Pol variants resulted in recombinant viruses that replicated with reduced kinetics in both T cell lines and peripheral blood mononuclear cells.
We found 12 SNPs that replicated, with 7 SNPs showing p-values of less than 10−5 when the discovery and replication cohorts were combined.
There were 22 SNP-SNP models that replicated with an LRT P-value < 0.01 (Fig. 3).
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Further, we recommend that six medium control wells or four wells each for both medium control and experimental conditions be performed to increase the sensitivity in detecting a response, that replicates with large variation in spot counts be filtered out, and that positive responses arising from experimental spot counts below the estimated limit of detection be interpreted with caution.
The remaining eight highly variable replicates were reported by six laboratories, implying that replicates with extremely high variation do not occur randomly across all participating laboratories but rather accumulate in a few centers.
In addition to applying a ST, we further recommend that replicates with variability greater than 10, defined as the sample variance of the replicates/ median of the replicates + 1), should be excluded and/or re-run prior to response determination as replicates with such high variation are likely to be artefacts and should not be considered reliable to use for response determination (Fig. 2).
Over productions that harken back to classic west coast gangsta rap, Giovanni lays his mack down with parading verses that replicate cruising with the top down.
This investigation provides evidence that total specimen height loss is not an accurate depiction of cycle-varying changes in the IVD across a range of in vivo scenarios that were replicated with in vitro testing.
We found that 137 replicated with FDR <0.05, 131 of which had the same direction of effect (Supplementary file 1B).
The invention uses piezoelectricity, a mechanical phenomenon that replicates that effect with crystals.
Now, the creator of Grindr has launched a new app Blendr that replicates Grindr's template, with one key twist: it allows women to register, too.
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CEO of Professional Science Editing for Scientists @ prosciediting.com