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Taken together, our data suggest that LvB52 acts as a splicing activator that regulates AS events in LvDscam.
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RBPs that regulate AS are believed to predominantly act through direct binding to regulatory RNA sequence motifs in the exons and/or flanking intronic sequences of alternatively spliced exons (Fu and Ares, 2014).
Cyclooxygenase catalyzes a key step in the biosynthesis of prostaglandins (PGs), a family of bioactive lipids that regulate as diverse biological processes as inflammation, pain, immunity, nerve and bone homeostasis among many others.
To look for the cellular substrate of differences in vulnerability, we began by examining synaptic patterns in the hippocampus, a brain region that regulates anxiety as well as plasticity throughout life.
Aβ-Al appears to be largely involved in the molecular machinery that regulates neuronal as well as synaptic dysfunction and loss.
It induces HIF1α, a transcription factor that regulates angiogenesis as well as cell survival, invasion and metastasis by activating transcription of a host of target genes.
S1P is a bioactive sphingolipid that regulates many physiological as well as pathophysiological processes in the vasculature and immune systems [ 7, 8].
It is therefore imperative to understand the factors that regulate normal, as well as abnormal, protein recycling in neurons.
Interesting outcomes from the fasted adipose tissue data include a strong enrichment of upregulated genes coding for proteins that regulate transcription as well as apoptosis-related genes.
FXR is a nuclear receptor that regulates bile acid synthesis as well as lipid and glucose metabolism [1].
Perry said he also hopes legislators will use their next session to pass a law that regulates abortion clinics as if they were surgical centers.
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