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As it is not possible for a tumour to correct large-scale rearrangements, the most plausible explanation under the clonal-selection hypothesis is that rearranged clones were eliminated by the treatment, leading to expansion of an ancestral clone with a related, but simpler, profile.
Out went forgotten classics, in came big, contemporary plays staged with punch and panache: shows like Enron, Lucy Prebble's freewheelingfinancial vaudeville, and a Dr Faustus that rearranged Marlowe around the Chapman brothers defacing works by Goya.
Taken together these results indicated that rearranged segments do not confer any selective growth advantage to viruses sharing the same genetic background.
Indeed, while both NSP3 and mNSP3 proteins were detected at passage 3, only mNSP3 was detected at passage 9. Taken together these results indicated that rearranged RNA segments segregated preferentially to their wt heterologous counterparts in reassortant viral progenies resulting from mixed infection by two RV with heterologous genetic backgrounds.
By performing competitive experiments between human r-RV and the bovine wt-RV strain RF, chosen for its major growth advantage over human RV, we show here that rearranged segments 7 and/or 11 of the human RV also underwent preferential segregation in the heterologous genetic background of the bovine RV, replacing the wt segment in the viral progenies.
Hughes et al. [ 30] suggested that rearranged genomes could allow to overcome the immune system of the host.
Similar(37)
Not surprising, then, that a rearranged meeting that evening is cut short by BMA officials, who need him to begin drawing up a strategy for these conversations.
It seems that the rearranged hopanes show no covariance with some terpanes.
It ought to been mentioned that the rearranged compounds 35 and 39 exhibited relatively higher HIV inhibitory effect.
It was observed that the rearranged T-cell receptor β count correlated well with total lymphocyte counts from both study populations (Baltimore R = 0.602, Uganda R = 0.497; p < 0.001) and the ability for this measurement to determine antiretroviral initiation was similar to total lymphocyte counts, which can be used to determine eligibility in HIV + children.
Our analyses identified that overall, rearranged regions had recombination frequencies about half of those around syntenic regions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com