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Using an in vitro system Gomes et al. [156] have observed that rather low doses of some delta-selective ligands can lead to a significant increase in the binding of a mu receptor agonist.
It should be noted that rather low toxicity of the proposed carrier has been observed.
The data suggest that rather low mortality rates can be expected when the patient suffers from isolated respiratory failure but that these increase exponentially when additional organ dysfunctions occur.
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The experiments with mice and rats showed that the rather low brain uptake of [11C]AZ10419369 during baseline condition could be increased significantly with the use of CsA.
Failure of the compost with 50% maize straw to heat up to thermophilic levels may indicate that the rather low moisture content (50%) may have limited microbial activity in the mixture.
It is also possible that the rather low confidence in authorities and manufacturers is one of the reasons for the high personal interest and private engagement of the study participants.
Here, it has to be considered that the rather low sensitivity of sensory signs results in limitations of diagnostic certainty [ 19].
This may lead to a poorer linkage to this particular work place, meaning that the rather low response rate should not reduce the validity of the patient safety assessment in OOH clinics very much.
It should also be noted that the rather low G + C content of the AICE (65.56%) might have introduced a similar amplification bias during the library preparation as discussed above for the rrn operons.
However, it is known that the rather low affinity of synaptotagmin 1 for Ca2+ (Ubach et al., 1998; Fernandez et al., 2001) can be strongly affected by the presence of synaptotagmin-binding partners, especially membrane lipids (Chapman, 2002).
Of note, it is likely that the rather low percentage of EdU+ SCs with γH2AX foci at 3 DIV is an underestimate, because a part of the foci had already been resolved by this time point.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com