When comparing Riesia to other insect p-endosymbionts, we find that nucleotide substitution rates decrease dramatically as the age of endosymbiosis increases.
This dataset includes a score for each nucleotide, ranging from 0 to 1, that provides a measure of conservation level of that nucleotide among placental mammals.
Recent studies show that Ipaf [9] and NALP3 [10] selectively bind ATP/dATP and that nucleotide binding is essential for their function in downstream signaling.
This suggests that nucleotide content is a selected trait.
One consideration is that nucleotide substitution directly influences the transcription of the gene.
We conclude that only CTP stimulates assembly and that nucleotide substrates, UTP and ATP, stimulate disassembly.
Read, number of reads calling variant/number of reads aligned at that nucleotide.
On the other hand, if the neighborhood is free from NXRs then the NXScore for that nucleotide will be zero.
Previous studies have suggested that nucleotide sequence divergence is high, up to 22% between some LCMVs (8 – 10 ).
A recent survey highlighted that nucleotide sequence polymorphism appears in all gene regions, both coding and non-coding [ 8].
The indicate that there were identified possible amino acids encoded by the SNPs at that nucleotide position.
