While a large fraction of recurrent and/or conserved mutations can directly or indirectly be considered NAMs as they typically perturb signaling networks (as exemplified here with BRAF V600E) and they typically operate as functional driver mutations, in this study we have demonstrated that non-recurrent and non-conserved mutations also can be functional NAMs.
This can probably be explained by the fact that women with non recurrent AUC are otherwise healthy subjects, uncommonly exposed to antibiotics and thus to any ecological adverse effect on their gut flora.
Student t-test showed that mean Topo II- α labelling index (LI) in recurrent cases was significantly higher than that in non-recurrent cases (P = 0.0001).
The recurrent cases tended to be milder than non-recurrent cases, which could favour chronicity [ 1].
Expression of ANRIL in non recurrent and recurrent tumor samples.
Thus, in MA.14 it is not necessarily surprising that the mean OPN level of 60.7 ng/ml observed during the recurrence period, for women who developed recurrence, is similar to that found in non-recurrent patients in our pilot study.
Therefore, it is possible that in non-recurrent tumors, in which the POSTN module is repressed, the stroma has fewer interactions with tumor cells, somehow disabling metastasis development.
In contrast, green edges that were present in non-recurrent tumors form paths to both anti-apoptotic XIAP/ AKT2 and proapoptotic BAX and BAD gene functions.
Interestingly hTERT, MCM5, and PPP1CA were positive in all 7 samples with atypical cells grade 2 or grade 3 that were diagnosed as non-recurrent because no tumors were found at cystoscopy; however, all were diagnosed with a tumor in the follow-up period.
But history is different: it is concerned with exploring and understanding individual cases as individual, that is, unique, non-recurrent, changing and unstable.
For example, a 5-gene model was proposed that could segregate recurrent from non-recurrent cancer [ 5].
