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Rifampicin (RIF) and isoniazid (ISO) are first line combination drugs for treatment of tuberculosis (TB) that negatively interact with each other upon simultaneous release in acidic environment.
In the present study, we experimentally tested the hypothesis that the AF16 and HK104 populations contain mitochondrial and nuclear alleles that negatively interact to produce dysfunctional hybrids.
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However, given that plants seem to grow poorly on amino acids and our results revealed that amino acids negatively interact with mineral sources to further reduce plant growth and reproductive potential this led us to ask: Why does A. thaliana bother to capture amino acids?
AtMYBL2 is a transcriptional repressor that negatively regulates anthocyanin biosynthesis by interacting with TT8 and MBW complexes [ 33, 34].
miRNAs are a class of small noncoding RNAs that negatively regulate gene expression by interacting with the 3′ untranslated region (UTR) of protein-coding mRNA.
Because Yrt is a FERM protein that negatively regulates Crb by directly interacting with its FBM (Laprise et al., 2006), Yrt appeared as a likely candidate in mediating the foscrb Y10A mutant phenotype.
This indicates that in addition to negatively interact with LRP5, N-cadherin inhibits Wnt signaling by reducing endogenous Wnt ligand expression.
Finally, we found strong evidence that FRI and FLC negatively interact to reduce seed yields in the C24 and Col hybrids, largely explaining the poor performance of this hybrid in the diallel experiment.
The most common scenario for NPP motifs is that the negatively interacting gene pair is annotated within the same biochemical pathway but their gene products have not been shown to physically interact.
Further, in many models, it is stressed that symptoms of PTSD and psychosis negatively interact with each other [ 10, 84], that they share some symptoms (such as intrusions and paranoia), and that they share developmental and maintenance processes (e.g., a self-blaming attributional style and avoidance behavior) [ 84].
Herbs can sometimes negatively interact with medications, producing results that are undesirable and even dangerous.
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