Any discussion on QbD necessitates defining pharmaceutical quality, which is rather subjective.
The study in our population can be considered as an initial one that necessitates further studies to define the relation between RDW and different diabetic complications and its prognostic value.
As such this study necessitated defining the normal spectrum of XY lengths within pachytene spermatocytes from wild type mice.
Pragmatically, severe CAP can be defined as disease that necessitates admission to the intensive care unit (ICU) [ 1, 2], which is the definition used in many clinical trials.
Exacerbations are defined as an acute event characterized by worsening of a patient's respiratory symptoms beyond normal day-to-day variation that necessitates prednisolone and/or hospital admissions for COPD.
That necessitates a phone call, rather diminishing the blink concept.
That necessitates a near-addiction to the news.
That necessitates the ability and willingness to make choices.
That necessitates a change in the patient's treatment regimen.
That necessitates, at some level, a strategy that can be described as "calculated misery".
