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Most S. Typhimurium isolates from clinically ill animals in Minnesota were MDR, which emphasizes that MDR strains are prevalent animal pathogens (10 ).
This dependence coupled with the fact that MDR uses an exhaustive search approach also means that MDR would be very computationally inefficient for larger datasets as the number of combinations increases combinatorially with number of variables and combination order [ 18].
The panel decided that XDR strains should not be sent anywhere for proficiency testing but that MDR strains could be sent to countries that approve their entry and that have proper safety equipment.
The same CDC study found that MDR TB treatment cost $134,000 per case on average, rising to $430,000 for the most extensively resistant cases.
It is normally assumed that MDR strains present a biological cost for growth in the absence of drugs.
The WHO Green Light Committee recommends that MDR patients receive a fluoroquinolone when their culture results reveal a susceptible isolate [10].
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Finally, it was shown that MDR-selective toxicity of NSC73306 pertains to cells with intrinsic or acquired MDR.
In 2002, the World Health Organization amended its policy to acknowledge that MDR-TB should be treated.
It has been shown that MDR-1 is over-expressed in brain tissue (hippocampal neurons) in patients with refractory temporal lobe epilepsy.
Nevertheless, there is ample evidence that MDR-TB is a major problem in Africa.
Given the dynamic interplay between HIV and TB, it is not surprising that MDR-TB has complicated the picture.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com