Answering such key questions first requires sound understanding of natural mechanisms of virulence selection and, from that knowledge, taking account of ecologic features that may select for HPAI viruses in artificial ecosystems.
To collect baseline pfserca sequence information before field deployment of Artemisinin-based Combination therapies that may select mutant parasites, we conducted a sequence analysis of 100 isolates from multiple sites in Africa, Asia and South America.
Potential reasons for the differential coverage of the proteome between proteomic methods are inherent differences in the techniques that may select for proteins with certain biophysical properties (though this is less likely with the Luminex approach in which the analytes are selected).
Several studies identified prognostic genes that may select high-risk patients for adjuvant treatment (Croner et al, 2008; Gray et al, 2011; Kennedy et al, 2011; Salazar et al, 2011; Nitsche et al, 2012; Maak et al, 2013).
Mutations in this pathway have previously been found in small colony variant (SCV) strains isolated from in vivo infections that are resistant to antibiotics, and our results suggest that heat stress is one condition that may select for these mutants.
This last mechanism has been previously found in plants [ 29, 30] and explained by the local scanning of the spliceosome that may select the best intron 3' splice site on the basis of sequence context [ 31].
