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Moreover, several psychoactive drugs produce blood pressure changes and alterations in respiratory frequency that may perturb central haemodynamic readouts of brain function.
There are also other more indirect consequences of human activity that may perturb marine carbon inventories [30], such as changes in fluvial sediment delivery to ocean [55], as well as climate change-driven ocean warming, deoxygenation, and acidification [20].
This observation suggests that many prognostic gene signatures contain only a smaller fraction of genes actually associated with outcome, and a significant proportion of passenger genes that may perturb or even have a detrimental effect on the prognostic performance.
Earlier methods have relied on procedures that may perturb normal cell metabolism; for example, drugs such as rifampicin [13], [28], radioactive tracers [13] and the introduction of engineered plasmids carrying reporter genes [14], [23] have all been used.
Then they can develop high-throughput screens to identify toxicants that may perturb those mechanisms.
One mechanism that may perturb the trajectory of male gestations during economic downturns involves reduced maternal sleep.
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We therefore tested the hypothesis that SNHL may perturb the maturation of processes that underlie shortening of sIPSC durations following hearing onset.
Here, we define pVDCs to include compounds that may directly perturb processes fundamental to vascular development.
Interestingly, it appeared that verapamil had some propensity to modulate P-gp expression (Fig. 5a), suggesting that it may perturb P-gp function through mechanisms other than direct inhibition of the efflux protein.
Anti-retroviral therapy regimens that include HIV protease inhibitors (PIs) are associated with diverse adverse effects including increased prevalence of oral warts, oral sensorial deficits and gastrointestinal toxicities suggesting that PIs may perturb epithelial cell biology.
Analysis of the molecular model of the mutant enzyme showed that Ile71 may perturb the conformation of important amino acid residues in the linker region which directly affects the catalytic function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com